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Looks like Greasemonkey removed GM_registerMenuCommand: https://wiki.greasespot.net/GM_registerMenuCommand.
This means that in Greasemonkey, it's harder to set options (due to the setting of options having to occur in the script's code itself now).
Script error in [Greasemonkey script http://fuzetsu.acypa.com/Auto Close YouTube Ads; version 1.4.1]: ReferenceError: GM_registerMenuCommand is not defined